Some of the nonsense is several levels down, so look at every level you can!.
You can turn off much of the background nonsense, and dial-down the MS telemetry - by going through your Windows 10 Settings screens one by one, and turning off nonsense that doesn't need to run. (even the Photos app has a curious habit of hogging resources). background updating, version-checking, configuring, & notifications by many of the Win10 'apps'. There have been a lot of "Cumulative Updates" lately, so some of the lagging performance might be due to the updates downloading in the background, Microsoft "telemetry" traffic. Perhaps it's background activity or traffic causing the audio trouble. Try checking through your Bios settings again, and try creating a Latency Monitor chart with the highest hard pagefaults at the top of the list.
It's not unusual, too, for Latency Monitor to have the highest latency numbers when testing - that's why it's a good idea to test both with it running and with it not running ("test by ear"). The counts don't look so bad in either chart. I think I am on the right track with this, just need a little extra help. I have included a screenshot of latencymon below. I dont know if I was on the right track with this or not. I have updated this to the latest beta 3.1.9.0 driver. This is the Asmedia 106x SATA host controller. Now latencymon is saying that it is causing the most lag.
I upgraded my SATA drivers to try to fix this. I basically found that the windows storport and miniport drivers were causing severe lag. I have researched similar problems on other forums without much success. I have also performed 2 complete system wipes and the problem returns.
This actually started happening in Windows 7 pro and I upgraded to 10 to see if this would help the problem. I bought the Soundblaster Z just in case it was the motherboard. I have updated the BIOS, all my drivers that I can possibly find, video card, etc. It occurs in all settings, from streaming music, to listening to mp3s, to playing games. I can usually tell when it is going to occur because startup time (usually about 7 seconds) is much delayed). Interestingly, it doesnt occur with every boot. The problem: intermittent cracking in sound and system/mouse lag every few seconds. Thermaltake 750 watt modular power supply I have been working on this problem when I have time for the past several months without a solution.